A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)

被引：19

作者：

Probst, FJ

Chen, KS

Zhao, Q

Wang, AH

Friedman, TB

Lupski, JR

Camper, SA

机构：

[1] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Dept Pediat, Houston, TX 77030 USA

[4] Michigan State Univ, Grad Program Genet, E Lansing, MI 48824 USA

[5] Natl Inst Deafness & Other Commun Disorders, Mol Genet Lab, NIH, Rockville, MD 20850 USA

来源：

GENOMICS | 1999年 / 55卷 / 03期

关键词：

D O I：

10.1006/geno.1998.5669

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the construction of a physical map of the region of mouse chromosome 11 that encompasses shaker-2 (sh2), a model for the human nonsyndromic deafness DFNB3. DFNB3 maps within the common deletion region of Smith-Magenis syndrome (SMS), del(17) (p11.2p11.2). Eleven of the genes mapping within the SMS common deletion region have murine homologs on the sh2 physical map. The gene order in this region is not perfectly conserved between mouse and human, a finding to be considered as we engineer a mouse model of Smith-Magenis syndrome. (C) 1999 Academic Press.

引用

页码：348 / 352

页数：5

共 29 条

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