Mechanisms involved in the regulation of histone lysine demethylases

被引：224

作者：

Lan, Fei ^{[1
]}

Nottke, Amanda Clair ^{[1
]}

Shi, Yang ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 03期

关键词：

D O I：

10.1016/j.ceb.2008.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.

引用

页码：316 / 325

页数：10

共 68 条

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