Predictions of capillary oxygen transport in the presence of fluorocarbon additives

被引:21
作者
Eggleton, CD
Roy, TK
Popel, AS [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Ctr Computat Med & Biol, Baltimore, MD 21205 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1998年 / 275卷 / 06期
关键词
mass transfer coefficient; mathematical model; hamster retractor muscle; microcirculation; blood substitute;
D O I
10.1152/ajpheart.1998.275.6.H2250
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A mathematical model of capillary oxygen transport was formulated to determine the effect of increasing plasma solubility, e.g., by the addition of an intravascular fluorocarbon emulsion. The effect of increased plasma solubility is studied for two distributions of fluorocarbon, when the fluorocarbon droplets are uniformly distributed throughout the plasma and when the fluorocarbon droplets are concentrated in a layer adjacent to the endothelium. The model was applied to working hamster retractor muscle at normal and lowered hematocrit. The intracapillary mass transfer coefficient was found to increase by 18% as the solubility was increased by a factor of 1.7 at a hematocrit of 43%. An additional increase of 6% was predicted when the solubility increase was concentrated in the layer adjacent to the endothelium. At a hematocrit of 25%, the intracapillary mass transfer coefficient increased 14% when the solubility was increased by a factor of 1.7.
引用
收藏
页码:H2250 / H2257
页数:8
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