Analysis of inhibitory effects of Scutellariae Radix and baicalein on prostaglandin E2 production in rat C6 glioma cells

被引:42
作者
Nakahata, N [1 ]
Kutsuwa, M [1 ]
Kyo, R [1 ]
Kubo, M [1 ]
Hayashi, K [1 ]
Ohizumi, Y [1 ]
机构
[1] Tohoku Univ, Fac Pharmaceut Sci, Dept Pharmaceut Mol Biol, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源
AMERICAN JOURNAL OF CHINESE MEDICINE | 1998年 / 26卷 / 3-4期
关键词
D O I
10.1142/S0192415X9800035X
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Inhibitory mechanism of the water extract of Scutelliariae Radix an prostaglandin E-2 (PGE(2)) release was examined in C6 rat glioma cells. Scutellariae Radix reduced a Ca2+ ionophore A23187-induced PGE(2) release by inhibition of arachidonic acid (AA) liberation. Sho-saiko-to and San'o-shashin-to, which contain Scutellariae Radix, also inhibited PGE(2) release. A23187 caused phosphorylation of mitogen-activated protein kinase (MAPK), resulting in activation of cytosolic phospholipase A(2) (cPLA(2)). Scutellariae Radix and baicalein inhibited the phosphorylation of MAPK. Baicalein, but not baicalin, inhibited A23187-induced PGE(2) release. These results suggest that baicalein in Scutellariae Radix reduces AA liberation through the inhibition of the MAPK-cPLA(2) pathway.
引用
收藏
页码:311 / 324
页数:14
相关论文
共 34 条
[1]  
BERGER ME, 1992, J PHARMACOL EXP THER, V263, P78
[2]  
CHANG WS, 1993, ANTICANCER RES, V13, P2165
[3]  
CHATANI Y, 1992, J BIOL CHEM, V267, P9911
[4]   A NOVEL ARACHIDONIC ACID-SELECTIVE CYTOSOLIC PLA2 CONTAINS A CA2+-DEPENDENT TRANSLOCATION DOMAIN WITH HOMOLOGY TO PKC AND GAP [J].
CLARK, JD ;
LIN, LL ;
KRIZ, RW ;
RAMESHA, CS ;
SULTZMAN, LA ;
LIN, AY ;
MILONA, N ;
KNOPF, JL .
CELL, 1991, 65 (06) :1043-1051
[5]  
DAVIS RJ, 1993, J BIOL CHEM, V268, P14553
[6]   PERTUSSIS AND CHOLERA TOXINS INHIBIT PROSTAGLANDIN SYNTHESIS IN RAT ASTROCYTE CULTURES AT DISTINCT METABOLIC STEPS [J].
GEBICKEHAERTER, PJ ;
SCHOBERT, A ;
HERTTING, G .
BIOCHEMICAL PHARMACOLOGY, 1991, 42 (06) :1267-1271
[7]   ANTIPROLIFERATIVE EFFECT OF BAICALEIN, A FLAVONOID FROM A CHINESE HERB, ON VASCULAR SMOOTH-MUSCLE CELL [J].
HUANG, HC ;
WANG, HR ;
HSIEH, LM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 251 (01) :91-93
[8]   A comparative study of arachidonic acid metabolism in rabbit cultured astrocytes and human astrocytoma cells (1321N1) [J].
Ishimoto, H ;
Matsuoka, I ;
Nakanishi, H ;
Nakahata, N .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1996, 27 (02) :313-317
[9]   Effects of ATP on phosphoinositide hydrolysis and prostaglandin E-2 generation in rabbit astrocytes [J].
Ishimoto, H ;
Nakahata, N ;
Matsuoka, I ;
Nakanishi, H .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (05) :520-524
[10]  
LI BQ, 1993, CELL MOL BIOL RES, V39, P119