Cell penetrating peptide-mediated systemic siRNA delivery to the liver

被引：48

作者：

Hayashi, Yasuhiro ^{[1
]}

Yamauchi, Jun ^{[1
]}

Khalil, Ikramy A. ^{[1
]}

Kajimoto, Kazuaki ^{[1
]}

Akita, Hidetaka ^{[1
]}

Harashima, Hideyoshi ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Lab Mol Design Pharmaceut, Grad Sch Pharmaceut Sci,Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2011年 / 419卷 / 1-2期

关键词：

Cell penetrating peptide; Octaarginine; siRNA delivery; Liver; SMALL INTERFERING RNA; IN-VIVO DELIVERY; GENE-EXPRESSION; OCTAARGININE; NANOPARTICLES; LIPOSOMES; STRATEGY; LIPIDS;

D O I：

10.1016/j.ijpharm.2011.07.038

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The cell-penetrating peptide (CPP) is one of the most attractive tools for efficiently delivering biomolecules to a target organelle. Here, we describe the use of octaarginine (R8)-modified lipid nanoparticles for the efficient and targeted in vivo delivery of siRNA to the liver. In this study, SR-BI (a scavenger receptor class B, member 1) was targeted by this nanoparticle. Our results demonstrate that R8-modified lipid nanoparticles can be used for the efficient and targeted delivery of liver siRNA to induce the specific knock-down of an endogenous gene with minimum liver toxicity and immune response, and that this CPP based technology holds considerable promise for further in vivo biological applications of siRNA. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：308 / 313

页数：6

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