Synthesis of the C28 through C38 segment of okadaic acid using vinylogous urethane aldol chemistry: Part IV

被引：25

作者：

Dankwardt, JW ^{[1
]}

Dankwardt, SM ^{[1
]}

Schlessinger, RH ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(98)00974-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the C-28 through C-38 segment of the marine natural product okadaic acid was accomplished employing a highly enantio- and diasteroselective aldol condensation reaction of a chiral vinylogous urethane enolate. The stereocenter at C-29 was addressed utilizing a diastereoselective hydroboration reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4983 / 4986

页数：4

共 28 条

[1] CHEMISTRY OF BIS-SPIROACETALS - SYNTHESIS OF THE 1,6,8-TRIOXADISPIRO[4.1.5.3]PENTADECANE RING-SYSTEM [J].