Potent thrombin inhibitors that probe the S-1' subsite: Tripeptide transition state analogues based on a heterocycle-activated carbonyl group

被引：71

作者：

Costanzo, MJ

Maryanoff, BE

Hecker, LR

Schott, MR

Yabut, SC

Zhang, HC

AndradeGordon, P

Kauffman, JA

Lewis, JM

Krishnan, R

Tulinsky, A

机构：

[1] RW JOHNSON PHARMACEUT RES INST, SPRING HOUSE, PA 19477 USA

[2] MICHIGAN STATE UNIV, DEPT CHEM, E LANSING, MI 48824 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 16期

关键词：

HUMAN ALPHA-THROMBIN; HUMAN NEUTROPHIL ELASTASE; RAY CRYSTAL-STRUCTURE; KETOHETEROCYCLIC INHIBITORS; ARG CHLOROMETHYLKETONE; PROLYL ENDOPEPTIDASE; CYCLOTHEONAMIDE-A; IN-VITRO; KETOBENZOXAZOLES; INTERMEDIATE;

D O I：

10.1021/jm9603274

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3039 / 3043

页数：5

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