Neurogenesis in the adult hippocampus

被引：404

作者：

Ehninger, Dan ^{[1
,2
,3
]}

Kempermann, Gerd ^{[4
]}

机构：

[1] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Psychiat & Psychol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA

[4] Ctr Regenerat Therapies Dresden, D-01307 Dresden, Germany

来源：

CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期

关键词：

neural stem cells; precursor cells; adult neurogenesis; hippocampus; learning and memory;

D O I：

10.1007/s00441-007-0478-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

New neurons continue to be generated in two privileged areas of the adult brain: the dentate gyrus of the hippocampal formation and the olfactory bulb. Adult neurogenesis has been found in all mammals studied to date, including humans. The process of adult neurogenesis encompasses the proliferation of resident neural stem and progenitor cells and their subsequent differentiation, migration, and functional integration into the pre-existing circuitry. This article summarizes recent findings regarding the developmental steps involved in adult hippocampal neurogenesis and the possible functional roles that new hippocampal neurons might play.

引用

页码：243 / 250

页数：8

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