Label-Free Biosensing with Lipid-Functionalized Gold Nanorods

被引：71

作者：

Castellana, Edward T. ^{[1
]}

Gamez, Roberto C. ^{[1
]}

Russell, David H. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 12期

关键词：

SURFACE-PLASMON RESONANCE; MASS-SPECTROMETRY; AMPHOTERICIN-B; CANCER; DRUG; BIOMARKERS; RECEPTORS; PEPTIDES; PROTEINS; DELIVERY;

D O I：

10.1021/ja109936h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The fabrication of a label-free mass spectrometry and optical detection-based biosensor platform for the detection of low-abundance lipophilic analytes in complex mixtures is described. The biosensor consists of a lipid layer partially tethered to the surface of a gold nanorod. The effectiveness of the biosensor is demonstrated for the label-free detection of a lipophilic drug in aqueous solution and a lipopeptide in serum.

引用

页码：4182 / 4185

页数：4

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