High-sensitivity C-reactive protein levels fall during statin therapy in HIV-infected patients receiving ritonavir-boosted protease inhibitors

被引：38

作者：

Aslangul, Elisabeth ^{[2
,3
]}

Fellahi, Soraya ^{[4
,5
,6
]}

Assoumou, Lambert K. ^{[1
,7
]}

Bastard, Jean-Philippe ^{[4
,5
,6
]}

Capeau, Jacqueline ^{[4
,5
,6
]}

Costagliola, Dominique ^{[1
,7
,8
]}

机构：

[1] INSERM, U943, F-75625 Paris 13, France

[2] Univ Paris 05, Paris, France

[3] Hop Hotel Dieu, AP HP, Serv Med Interne, Paris, France

[4] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, France

[5] INSERM, U938, CDR St Antoine, F-75625 Paris 13, France

[6] Univ Paris 06, UMR S938, Paris, France

[7] Univ Paris 06, UMR S943, Paris, France

[8] Hop La Pitie Salpetriere, AP HP, Serv Malad Infect & Trop, Paris, France

来源：

AIDS | 2011年 / 25卷 / 08期

关键词：

MYOCARDIAL-INFARCTION RATES; ANTIRETROVIRAL THERAPY; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; INFLAMMATION; MARKERS; RISK; IMMUNODEFICIENCY; ROSUVASTATIN; ATORVASTATIN;

D O I：

10.1097/QAD.0b013e328346be29

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-infected patients are at an increased risk of developing cardiovascular disease. Elevated levels of C-reactive protein (CRP) are associated with an increased risk of cardiovascular disease in the general population and are reduced by statin therapy. We examined the effect of pravastatin and rosuvastatin on CRP levels in 58 dyslipidemic HIV-infected patients. A 45-day course of either statin reduced the median CRP level from 3.0 to 2.4 mg/l (P < 0.001) with no correlation with changes in lipid parameters.

引用

页码：1128 / 1131

页数：4

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