T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis

被引：141

作者：

Blauvelt, Andrew ^{[1
,2
,3
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Vet Affairs Med Ctr, Dermatol Serv, Portland, OR 97201 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 05期

关键词：

D O I：

10.1038/jid.2008.85

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.

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页码：1064 / 1067

页数：4

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