The synthesis of (-)-Ambrox® starting from labdanolic acid

被引：35

作者：

Bolster, MG ^{[1
]}

Jansen, BJM ^{[1
]}

de Groot, A ^{[1
]}

机构：

[1] Univ Wageningen & Res Ctr, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands

来源：

TETRAHEDRON | 2001年 / 57卷 / 26期

关键词：

Ambrox((R)); labdanolic acid; iododecarboxylation;

D O I：

10.1016/S0040-4020(01)00493-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iododecarboxylation of labdanolic acid (1), followed by dehydrohalogenation led to alkenes 4 and 12. Both compounds were converted into (1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydro-2-naphthalenol (8), which was transformed via cyclization into (-)-Ambrox((R)) (9). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5657 / 5662

页数：6

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