Second malignancy in 597 patients with Ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999

被引：31

作者：

Bacci, G

Longhi, A

Barbieri, E

Ferrari, S

Mercuri, M

Briccoli, A

Versari, M

Pignotti, E

Picci, P

机构：

[1] Ist Ortoped Rizzoli, Dept Chemotherapy, I-40136 Bologna, Italy

[2] St Orsola Hosp, Dept Radiotherapy, Bologna, Italy

[3] Ist Ortoped Rizzoli, Dept Orthopaed Surg, I-40136 Bologna, Italy

[4] Ist Ortoped Rizzoli, Dept Thorac Surg, I-40136 Bologna, Italy

[5] Ist Ortoped Rizzoli, Dept Stat, I-40136 Bologna, Italy

[6] Ist Ortoped Rizzoli, Dept Basic Res, I-40136 Bologna, Italy

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2005年 / 27卷 / 10期

关键词：

Ewing sarcoma; second tumor; radiotherapy;

D O I：

10.1097/01.mph.0000183270.28785.33

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relative risk of second tumors in patients with Ewing sarcoma is controversial, and little is known about their treatment and outcome. The purpose of the current study was to define the incidence and features of second tumors among 597 longterm survivors of norunetastatic Ewing sarcoma treated with adjuvant and neoadjuvant chemotherapy, radiotherapy, and/or surgery. The authors found that the risk of secondary malignancy after adjuvant or neoadjuvant treatment of Ewing sarcoma is higher than that after other childhood or adolescent cancers only after radiotherapy. Based on this, postoperative radiotherapy should be avoided when surgery with adequate margins is feasible.

引用

页码：517 / 520

页数：4

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