Discovery of virulence factors of pathogenic bacteria

被引：195

作者：

Wu, Hsing-Ju ^{[1
]}

Wang, Andrew H-J ^{[1
]}

Jennings, Michael P. ^{[2
,3
]}

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

[2] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia

[3] Univ Queensland, Ctr Met Biol, Brisbane, Qld 4072, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2008年 / 12卷 / 01期

关键词：

D O I：

10.1016/j.cbpa.2008.01.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Discovering virulence factors of pathogenic bacteria is a key in understanding pathogenesis and for identification of targets for novel drugs and design of new vaccines. Comparative genomics, transcriptomics, and proteornics have become the popular tools in discovering the virulence factors in bacterial pathogens, such as Neisseria meningitidis, Yersinia pestis, Mycobacterium tuberculosis, and Staphylococcus aureus. In addition, proteomics has been employed successfully in the study of the mechanism of post-translationally modified proteins of bacterial pathogens. Once the putative virulence factors are identified by genomics and/or proteomics, their functions and mechanisms can be further investigated by phenotypic analyses including mutagenesis and biochemical methods and/or structural biology. Combination of these techniques will accelerate the developments of therapeutic drugs and vaccines in combating bacterial diseases.

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页码：93 / 101

页数：9

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