Carotenoids are degraded by free radicals but do not affect lipid peroxidation in unilamellar liposomes under different oxygen tensions

被引：42

作者：

Chen, G ^{[1
]}

Djuric, Z ^{[1
]}

机构：

[1] Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USA

来源：

FEBS LETTERS | 2001年 / 505卷 / 01期

关键词：

carotenoid; liposome; lipid peroxidation; free radical;

D O I：

10.1016/S0014-5793(01)02671-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been questioned whether carotenoids can act as antioxidants in biological membranes. Biological membranes can be modeled for studies of lipid peroxidation using unilamellar liposomes. Both carotenoid depletion and lipid peroxidation were increased with increasing oxygen tension in unilamellar liposomes. Carotenoids in such liposomes. were found to be very sensitive to degradation by free radicals generated from iron and 2,2'-azobis(2-amidinopropane) dihydro chloride, but they were not protective against lipid peroxidation. Lycopene and beta -carotene were more sensitive to free radical attack than lutein, zeaxanthin, and beta -cryptoxanthin. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：151 / 154

页数：4

相关论文

共 24 条

[1]

[Anonymous], 1995, CAROTENOIDS

[2] SINGLE BILAYER LIPOSOMES PREPARED WITHOUT SONICATION [J].

BATZRI, S ;

KORN, ED .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 298 (04) :1015-1019

[3] A multicenter case-control study of diet and lung cancer among non-smokers [J].

Brennan, P ;

Fortes, C ;

Butler, J ;

Agudo, A ;

Benhamou, S ;

Darby, S ;

Gerken, M ;

Jöckel, KH ;

Kreuzer, M ;

Mallone, S ;

Nyberg, F ;

Pohlabeln, H ;

Ferro, G ;

Boffetta, P .

CANCER CAUSES & CONTROL, 2000, 11 (01) :49-58

[4]

BURDON R, 1991, LAB TECHNIQUES BIOCH

[5] BETA-CAROTENE - AN UNUSUAL TYPE OF LIPID ANTIOXIDANT [J].

BURTON, GW ;

INGOLD, KU .

SCIENCE, 1984, 224 (4649) :569-573

[6] Zeaxanthin (dihydroxy-beta-carotene but not beta-carotene rigidifies lipid membranes: A H-1-NMR study of carotenoid-egg phosphatidylcholine liposomes [J].

Gabrielska, J ;

Gruszecki, WI .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1996, 1285 (02) :167-174

[7] Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum [J].

Khachik, F ;

Spangler, CJ ;

Smith, JC ;

Canfield, LM ;

Steck, A ;

Pfander, H .

ANALYTICAL CHEMISTRY, 1997, 69 (10) :1873-1881

[8] Does β-carotene protect membrane lipids from nitrogen dioxide? [J].

Khopde, SM ;

Priyadarsini, KI ;

Mukherjee, T ;

Kulkarni, PB ;

Satav, JG ;

Bhattacharya, RK .

FREE RADICAL BIOLOGY AND MEDICINE, 1998, 25 (01) :66-71

[9] Metabolites of dietary carotenoids as potential cancer preventive agents [J].

King, TJ ;

Khachik, F ;

Bortkiewicz, H ;

Fukushima, LH ;

Morioka, S ;

Bertram, JS .

PURE AND APPLIED CHEMISTRY, 1997, 69 (10) :2135-2140

[10] Antioxidant actions of beta-carotene in liposomal and microsomal membranes: Role of carotenoid-membrane incorporation and alpha-tocopherol [J].

Liebler, DC ;

Stratton, SP ;

Kaysen, KL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 338 (02) :244-250