The distribution of macrophages in spiral arteries of the placental bed in pre-eclampsia differs from that in healthy patients

被引:111
作者
Reister, F
Frank, HG
Heyl, W
Kosanke, G
Huppertz, B
Schröder, W
Kaufmann, P
Rath, W
机构
[1] Aachen Tech Univ, Dept Obstet & Gynecol, D-52057 Aachen, Germany
[2] Aachen Tech Univ, Dept Anat, D-52057 Aachen, Germany
关键词
D O I
10.1053/plac.1998.0373
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Placental bed biopsies taken during caesarean section from 10 patients with pre-eclampsia and six healthy pregnancies were studied. We applied antibodies against cytokeratin and different macrophage markers to analyse the distribution of invasive estravillous trophoblast cells as compared to that of macrophages in myometrial segments of uteroplacental arteries. The data were evaluated quantitatively. We found a clear inverse relationship between local infiltration with macrophages and trophoblast invasion. In pre-eclampsia, vessel cross-sections prevailed which were characterized by large numbers of macrophages but a low degree of trophoblast invasion. In contrast, in normal third trimester pregnancies the respective arterial segments had a high degree of trophoblast invasion but were largely void of macrophages. These data suggest causal links between macrophages and inhibition of intra-arterial trophoblast invasion in pre-eclampsia. (C) 1999 W. B. Saunders Company Ltd.
引用
收藏
页码:229 / 233
页数:5
相关论文
共 28 条
[1]   PHYSIOLOGICAL RESPONSE OF VESSELS OF PLACENTAL BED TO NORMAL PREGNANCY [J].
BROSENS, I ;
ROBERTSON, WB ;
DIXON, HG .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1967, 93 (02) :569-+
[2]  
Brosens I A, 1972, Obstet Gynecol Annu, V1, P177
[3]  
Brosens I. A., 1970, J PATHOL, V101
[4]  
DEFILIPPI P, 1992, J BIOL CHEM, V267, P18303
[5]   BETA-1 INTEGRINS IN 3RD-TRIMESTER HUMAN PLACENTAE - NO DIFFERENTIAL EXPRESSION IN PATHOLOGICAL PREGNANCY [J].
DIVERS, MJ ;
BULMER, JN ;
MILLER, D ;
LILFORD, RJ .
PLACENTA, 1995, 16 (03) :245-260
[6]  
FRANK HG, 1994, ACTA ANAT, V150, P55
[7]  
GAUS G, 1997, TROPHOBLAST RES, V10, P181
[8]  
HOHENAUER L, 1980, Z GEBURTSH PERINATOL, V184, P167
[9]   Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta [J].
Huppertz, B ;
Frank, HG ;
Kingdom, JCP ;
Reister, F ;
Kaufmann, P .
HISTOCHEMISTRY AND CELL BIOLOGY, 1998, 110 (05) :495-508
[10]   FUNCTIONAL-ROLE OF CELL-SURFACE INTEGRINS ON HUMAN TROPHOBLAST CELL-MIGRATION - REGULATION BY TGF-BETA, IGF-II, AND IGFBP-1 [J].
IRVING, JA ;
LALA, PK .
EXPERIMENTAL CELL RESEARCH, 1995, 217 (02) :419-427