MHC polymorphism: AIDS susceptibility in non-human primates

被引：62

作者：

Bontrop, RE

Watkins, DI

机构：

[1] Biomed Primate Res Ctr, Dept Comparat Genet & Refinement, NL-2280 GH Rijswijk, Netherlands

[2] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 04期

关键词：

D O I：

10.1016/j.it.2005.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the main host factors controlling resistance to disease appears to be the MHC. The recent poor results in HIV-1/AIDS Phase 3 vaccine field trials underline the importance of non-human primate models for AIDS. These models have been, and will continue to be, important for the definition of protective immune responses relevant to successful vaccine design because they supply essential information on the basic biology of lentivirus infections, mechanisms of resistance, escape and vaccine development.

引用

收藏

页码：227 / 233

页数：7

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