The TNF receptor 1: A split personality complex

被引：54

作者：

Barnhart, BC ^{[1
]}

Peter, ME ^{[1
]}

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

CELL | 2003年 / 114卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(03)00561-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The tumor necrosis factor receptor 1 (TNFR1), a prototypic member of the death receptor family signals both cell survival and apoptosis. In this issue of Cell, Micheau and Tschopp (2003) report that apoptotic TNFR1 signaling proceeds via the sequential formation of two distinct complexes. Since the first complex can activate survival signals and influence the activity of the second complex, this mechanism provides a checkpoint to control the execution of apoptosis.

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页码：148 / 150

页数：3

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