Effect of acetate and propionate on calcium absorption from the rectum and distal colon of humans

被引:105
作者
Trinidad, TP [1 ]
Wolever, TMS [1 ]
Thompson, LU [1 ]
机构
[1] UNIV TORONTO,DEPT NUTR SCI,FAC MED,TORONTO,ON M5S 1A8,CANADA
关键词
calcium absorption; acetate; propionate; butyrate; distal colon;
D O I
10.1093/ajcn/63.4.574
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To determine the effects of acetate and propionate on calcium absorption from the human distal colon and rectum, six healthy human subjects were given rectal infusions containing 50 mmol CaCl2/L on four separate occasions. Addition of 56.3 mmol acetate/L, 18.7 mmol propionate/L, or acetate and propionate together increased calcium disappearance (expressed as the change in the ratio of calcium to polyethylene glycol) from -5.5 +/- 1.4 to -22.6 +/- 2.8, -23.2 +/- 3.2, and -19.7 +/- 4.6, respectively; P < 0.05. To determine the effects of different acetate and propionate concentrations, six different subjects were studied further. The effects of 18.7 or 56.3 mmol acetate/L on calcium absorption were the same as those of 18.7 mmol propionate/L (-15.7 +/- 1.4), and less than those of 56.3 mmol propionate/L (-20.3 +/- 2.4, P < 0.05). We conclude that both acetate and propionate enhance calcium absorption from the human distal colon, but that propionate has a greater effect at higher concentrations. Further studies are needed to determine the mechanism of calcium absorption from the colon.
引用
收藏
页码:574 / 578
页数:5
相关论文
共 34 条
[1]   CALCIUM BIOAVAILABILITY AND ABSORPTION - A REVIEW [J].
ALLEN, LH .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1982, 35 (04) :783-808
[2]  
BERGER D, 1991, Gastroenterology, V100, pA349
[3]  
BIRD R, 1986, CARCINOGENESIS, V7, P1653
[4]  
BIRD R, 1986, DIETARY FAT CANC
[5]  
BLACKEBHORN DH, 1955, P EXP BIOL MED, V88, P356
[6]  
BRANCH WJ, 1975, P NUTR SOC, V34, pA120
[7]   CALCIUM AS AN INTRACELLULAR REGULATOR [J].
CAMPBELL, AK .
PROCEEDINGS OF THE NUTRITION SOCIETY, 1990, 49 (01) :51-56
[8]   ABSORPTION OF SHORT-CHAIN FATTY-ACIDS FROM THE RAT CECUM INVIVO [J].
FLEMING, SE ;
CHOI, SY ;
FITCH, MD .
JOURNAL OF NUTRITION, 1991, 121 (11) :1787-1797
[9]  
FURDA I, 1979, DIETARY FIBERS CHEM, P30
[10]   EFFECT OF DIETARY COPPER ON COLONIC TUMOR PRODUCTION AND AORTIC INTEGRITY IN THE RAT [J].
GREENE, FL ;
LAMB, LS ;
BARWICK, M ;
PAPPAS, NJ .
JOURNAL OF SURGICAL RESEARCH, 1987, 42 (05) :503-512