Structural model of the amyloid fibril formed by β2-microglobulin #21-31 fragment based on vibrational spectroscopy

被引：37

作者：

Hiramatsu, H

Goto, Y

Naiki, H

Kitagawa, T ^{[1
]}

机构：

[1] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787, Japan

[2] Osaka Univ, Inst Prot Res, Suita, Osaka 5650871, Japan

[3] Univ Fukui, Dept Med Sci, Fukui 9101193, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 22期

关键词：

D O I：

10.1021/ja050844o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A structural model of amyloid fibril formed by the #21-31 fragment of β2-microglobulin is proposed from microscope IR measurements on specifically 13C-labeled peptide fibrils and Raman spectra of the dispersed fibril solution. The 13C-shifted amide frequency indicated the secondary structure of the labeled residues. The IR spectra have demonstrated that the region between F22 and V27 forms the core part with the extended β-sheet structure. Raman spectra indicated the formation of a dimer with a disulfide bridge between C25 residues. Copyright © 2005 American Chemical Society.

引用

页码：7988 / 7989

页数：2

共 19 条

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