Evolution, language and analogy in functional genomics

被引:15
作者
Benner, SA [1 ]
Gaucher, EA [1 ]
机构
[1] Univ Florida, Dept Chem, NASA, Astrobiol Inst, Gainesville, FL 32611 USA
关键词
D O I
10.1016/S0168-9525(01)02320-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Almost a century ago, Wittgenstein pointed out that theory in science is intricately connected to language. This connection is not a frequent topic in the genomics literature. But a case can be made that functional genomics is today hindered by the paradoxes that Wittgenstein identified. If this is true, until these paradoxes are recognized and addressed, functional genomics will continue to be limited in its ability to extrapolate information from genomic sequences.
引用
收藏
页码:414 / 418
页数:5
相关论文
共 42 条
[1]  
AIMI J, 1990, J BIOL CHEM, V265, P9011
[2]  
Ayala FJ, 1999, BIOESSAYS, V21, P71, DOI 10.1002/(SICI)1521-1878(199901)21:1<71::AID-BIES9>3.3.CO
[3]  
2-2
[4]  
Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]
[5]   INTERPRETING THE BEHAVIOR OF ENZYMES PURPOSE OR PEDIGREE [J].
BENNER, S ;
ELLINGTON, AD .
CRC CRITICAL REVIEWS IN BIOCHEMISTRY, 1988, 23 (04) :369-426
[6]   Functional inferences from reconstructed evolutionary biology involving rectified databases - an evolutionarily grounded approach to functional genomics [J].
Benner, SA ;
Chamberlin, SG ;
Liberles, DA ;
Govindarajan, S ;
Knecht, L .
RESEARCH IN MICROBIOLOGY, 2000, 151 (02) :97-106
[7]   Post-genomic science: Converting primary structure into physiological function [J].
Benner, SA ;
Trabesinger, N ;
Schreiber, D .
ADVANCES IN ENZYME REGULATION, VOL 38, 1998, 38 :155-180
[8]   EMPIRICAL AND STRUCTURAL MODELS FOR INSERTIONS AND DELETIONS IN THE DIVERGENT EVOLUTION OF PROTEINS [J].
BENNER, SA ;
COHEN, MA ;
GONNET, GH .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 229 (04) :1065-1082
[9]   Natural progression [J].
Benner, SA .
NATURE, 2001, 409 (6819) :459-459
[10]   Bona fide predictions of protein secondary structure using transparent analyses of multiple sequence alignments [J].
Benner, SA ;
Cannarozzi, G ;
Gerloff, D ;
Turcotte, M ;
Chelvanayagam, G .
CHEMICAL REVIEWS, 1997, 97 (08) :2725-2843