Magic angle spinning NMR for reaction monitoring and structure determination of molecules attached to multipin crowns

被引:39
作者
Chin, J
Fell, B
Shapiro, MJ
Tomesch, J
Wareing, JR
Bray, AM
机构
[1] SANDOZ PHARMACEUT CORP,SANDOZ RES INST,PRECLIN RES,DEPT CENT TECHNOL,E HANOVER,NJ 07936
[2] SANDOZ PHARMACEUT CORP,SANDOZ RES INST,PRECLIN RES,DEPT COMBINATORIAL CHEM,E HANOVER,NJ 07936
关键词
D O I
10.1021/jo961590f
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first example of magic angle spinning NMR on crowns has been demonstrated. The ability to monitor a reaction on a crown and to confirm the structure of the reaction product directly on the crown without resorting to chemical cleavage should greatly enhance the utility of this convenient format for combinatorial chemistry.
引用
收藏
页码:538 / 539
页数:2
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