Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

被引：92

作者：

Cook, J

Krishnan, S

Ananth, S

Sells, SF

Shi, Y

Walther, MM

Linehan, WM

Sukhatme, VP

Weinstein, MH

Rangnekar, VM

机构：

[1] Univ Kentucky, Dept Surg, Div Urol, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Microbiol & Immunol, Lexington, KY 40536 USA

[4] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40536 USA

[5] Beth Israel Deaconess Med Ctr, Div Renal, Boston, MA USA

[6] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[7] Harvard Univ, Sch Med, Dept Pathol, Boston, MA USA

[8] NCI, Urol Oncol Sect, NIH, Bethesda, MD 20892 USA

来源：

ONCOGENE | 1999年 / 18卷 / 05期

关键词：

Par-4; renal cell carcinoma; apoptosis;

D O I：

10.1038/sj.onc.1202416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors, We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells, Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis, Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

引用

页码：1205 / 1208

页数：4

共 21 条

[1] Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade [J].

Berra, E ;

Municio, MM ;

Sanz, L ;

Frutos, S ;

DiazMeco, MT ;

Moscat, J .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) :4346-4354

[2]

Boghaert ER, 1997, CELL GROWTH DIFFER, V8, P881

[3] GERMLINE MUTATIONS IN THE VONHIPPEL-LINDAU DISEASE TUMOR-SUPPRESSOR GENE - CORRELATIONS WITH PHENOTYPE [J].

CHEN, F ;

KISHIDA, T ;

YAO, M ;

HUSTAD, T ;

GLAVAC, D ;

DEAN, M ;

GNARRA, JR ;

ORCUTT, ML ;

DUH, FM ;

GLENN, G ;

GREEN, J ;

HSIA, YE ;

LAMIELL, J ;

LI, H ;

WEI, MH ;

SCHMIDT, L ;

TORY, K ;

KUZMIN, I ;

STACKHOUSE, T ;

LATIF, F ;

LINEHAN, WM ;

LERMAN, M ;

ZBAR, B .

HUMAN MUTATION, 1995, 5 (01) :66-75

[4]

CROSSEY PA, 1994, HUM MOL GENET, V3, P1303

[5] The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C [J].

DiazMeco, MT ;

Municio, MM ;

Frutos, S ;

Sanchez, P ;

Lozano, J ;

Sanz, L ;

Moscat, J .

CELL, 1996, 86 (05) :777-786

[6] SOMATIC MUTATIONS OF THE VON HIPPEL-LINDAU DISEASE TUMOR-SUPPRESSOR GENE IN NONFAMILIAL CLEAR-CELL RENAL-CARCINOMA [J].

FOSTER, K ;

PROWSE, A ;

VANDENBERG, A ;

FLEMING, S ;

HULSBEEK, MMF ;

CROSSEY, PA ;

RICHARDS, FM ;

CAIRNS, P ;

AFFARA, NA ;

FERGUSONSMITH, MA ;

BUYS, CHCM ;

MAHER, ER .

HUMAN MOLECULAR GENETICS, 1994, 3 (12) :2169-2173

[7] MUTATIONS OF THE VHL TUMOR-SUPPRESSOR GENE IN RENAL-CARCINOMA [J].

GNARRA, JR ;

TORY, K ;

WENG, Y ;

SCHMIDT, L ;

WEI, MH ;

LI, H ;

LATIF, F ;

LIU, S ;

CHEN, F ;

DUH, FM ;

LUBENSKY, I ;

DUAN, DR ;

FLORENCE, C ;

POZZATTI, R ;

WALTHER, MM ;

BANDER, NH ;

GROSSMAN, HB ;

BRAUCH, H ;

POMER, S ;

BROOKS, JD ;

ISAACS, WB ;

LERMAN, MI ;

ZBAR, B ;

LINEHAN, WM .

NATURE GENETICS, 1994, 7 (01) :85-90

[8]

GUO Q, 1998, IN PRESS NAT MED

[9] TUMOR SUPPRESSION BY THE HUMAN VON HIPPEL-LINDAU GENE-PRODUCT [J].

ILIOPOULOS, O ;

KIBEL, A ;

GRAY, S ;

KAELIN, WG .

NATURE MEDICINE, 1995, 1 (08) :822-826

[10]

KERR JFR, 1994, CANCER-AM CANCER SOC, V73, P2013, DOI 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO

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