Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury

被引：119

作者：

García-Estrada, J

Luquín, S

Fernández, AM

Garcia-Segura, LM ^{[1
]}

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

[2] Inst Mexicano Seguro Social, Unidad Invest Biomed Occidente, Guadalajara, Jalisco, Mexico

[3] Univ Guadalajara, Guadalajara 44430, Jalisco, Mexico

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1999年 / 17卷 / 02期

关键词：

cerebral cortex; hippocampal formation; astroglia; dehydroepiandrosterone; pregnenolone; testosterone; estradiol; progesterone; brain repair;

D O I：

10.1016/S0736-5748(98)00065-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Astrocytes are a target for steroid hormones and for steroids produced by the nervous system (neurosteroids). The effect of gonadal hormones and several neurosteroids in the formation of gliotic tissue has been assessed in adult male rats after a penetrating wound of the cerebral cortex and the hippocampal formation. The hormones testosterone, 17 beta-estradiol and progesterone and the neurosteroids dehydroepiandrosterone, pregnenolone and pregnenolone sulfate resulted in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes. Of all steroids tested, dehydroepiandrosterone was the most potent inhibitor of gliotic tissue formation. These findings suggest that neurosteroids and sex steroids may affect brain repair by down-regulating gliotic tissue. (C) 1999 ISDN. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：145 / 151

页数：7

共 22 条

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