Soluble intercellular adhesion molecule 1 in spondylarthropathies

被引：19

作者：

Wendling, D ^{[1
]}

Racadot, E ^{[1
]}

Auge, B ^{[1
]}

Toussirot, E ^{[1
]}

机构：

[1] CHRU Besancon, Hop Jean Minjoz, Serv Rhumatol, F-25030 Besancon, France

来源：

CLINICAL RHEUMATOLOGY | 1998年 / 17卷 / 03期

关键词：

adhesion molecules; soluble ICAM-1; spondyloarthropathy;

D O I：

10.1007/BF01451047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the study was to evaluate the soluble form of intercellular adhesion molecule 1 (sICAM-1), a ligand of LFA-1, in the serum of patients with spondylarthropathies (SpA) and to look for a correlation with several inflammatory parameters. sICAM-1 levels were measured by ELISA in 25 SpA patients, 20 healthy controls and 20 patients with rheumatoid arthritis (RA). Results showed that sICAM-1 levels were increased (but not significantly) in SpA patients compared with controls; high levels (>400 ng/ mi) where found in 28% of SpA patients but in none of the RA or control groups. In SpA, correlations were found between sICAM-1 and erythrocyte sedimentation rate, C-reactive protein and interleukin 6, but not with tumour necrosis factor alapha or IgA. These correlations were absent in RA. In conclusion, these results suggest that sICAM-1 levels in SpA may reflect the acute phase of inflammation.

引用

页码：202 / 204

页数：3

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