Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Tmp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively

被引：28

作者：

Olson, TM

Hirohata, S

Ye, J

Leco, K

Seldin, MF

Apte, SS

机构：

[1] Cleveland Clin Fdn Wb3, Lerner Res Inst, Dept Biomed Engn, Cleveland, OH 44195 USA

[2] Univ Utah, Hlth Sci Ctr, Primary Childrens Med Ctr, Div Pediat Cardiol, Salt Lake City, UT 84112 USA

[3] Univ Calif Davis, Dept Biol Chem, Rowe Program Genet, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Med, Davis, CA 95616 USA

[5] Princess Margaret Hosp, Ontario Reg Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

GENOMICS | 1998年 / 51卷 / 01期

关键词：

D O I：

10.1006/geno.1998.5362

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size to Timp1 but considerably smaller than TIMP2 and TIMP3. The exon-intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6. (C) 1998 Academic Press.

引用

页码：148 / 151

页数：4

共 22 条

[1] GENE ENCODING A NOVEL MURINE TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP), TIMP-3, IS EXPRESSED IN DEVELOPING MOUSE EPITHELIA, CARTILAGE, AND MUSCLE, AND IS LOCATED ON MOUSE CHROMOSOME-10 [J].