Stable binding of DNA to zwitterionic lipid bilayers in aqueous solutions

被引：30

作者：

Malghani, MS ^{[1
]}

Yang, J ^{[1
]}

机构：

[1] Univ Vermont, Dept Phys, Burlington, VT 05405 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 1998年 / 102卷 / 44期

关键词：

D O I：

10.1021/jp982413g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We found that DNA molecules bind strongly to zwitterionic dipalmitoylphosphatidylcholine lipid bilayers in solutions, facilitating in situ imaging with an atomic force microscope. The binding strength has a lower limit of about 2 kT per helical turn with kT the thermal energy at room temperature, The height of membrane-bound DNA is the same as the diameter of DNA, indicating no compression by the tip at a probe force of about 0.1 nN.

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页码：8930 / 8933

页数：4

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