Maternal serum and cord blood preptin levels in gestational diabetes mellitus

被引：31

作者：

Aslan, M.

Celik, O. ^{[2
]}

Karsavuran, N.

Celik, N. ^{[3
]}

Dogan, D. G. ^{[1
]}

Botan, E.

Kafkasli, A. ^{[2
]}

机构：

[1] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Pediat, TR-44315 Malatya, Turkey

[2] Inonu Univ, Sch Med, Dept Obstet & Gynecol, TR-44315 Malatya, Turkey

[3] Malatya State Hosp Beydagi Campus Biochem, Malatya, Turkey

来源：

JOURNAL OF PERINATOLOGY | 2011年 / 31卷 / 05期

关键词：

gestational diabetes mellitus; maternal serum; cord blood; preptin; insulin; GROWTH-FACTOR; GLUCOSE; PLASMA;

D O I：

10.1038/jp.2010.125

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess preptin concentrations in pregnant women with and without gestational diabetes mellitus (GDM) and in the cord blood of their fetuses. Study Design: In all, 31 pregnant women with GDM and 31 gestational age-matched healthy pregnant subjects participated. Maternal serum and cord blood preptin levels were measured with ELISA. The relationships between maternal serum and cord blood preptin levels, anthropometric and metabolic parameters were also assessed. Result: Maternal serum and cord blood preptin levels were found higher in patients with GDM compared with control pregnant women. Preptin concentration in maternal serum was positively correlated with maternal age, fasting insulin levels, 1-h blood glucose after glucose load and cord preptin concentrations at birth. However, relationships between maternal and/or cord serum preptin and fetal growth parameters at birth were not detected. Conclusion: Our results indicate that preptin concentrations increase in maternal serum of women with GDM. Preptin levels may provide a novel approach to identify women with GDM. Journal of Perinatology (2011) 31, 350-355; doi:10.1038/jp.2010.125; published online 16 December 2010

引用

页码：350 / 355

页数：6

共 9 条

[1] Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet β-cells and enhances insulin secretion [J].