Immuno suppressive flavones and lignans from Bupleurum scorzonerifolium

被引：45

作者：

Chang, WL ^{[1
]}

Chiu, LW

Lai, JH

Lin, HC

机构：

[1] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan

[2] Triserv Gen Hosp, Dept Med, Taipei 114, Taiwan

来源：

PHYTOCHEMISTRY | 2003年 / 64卷 / 08期

关键词：

Bupleurum scorzonerfolium; Umbelliferae; flavones; lignans; isochaihulactone; chaihunaphthone; immunosuppressive effect;

D O I：

10.1016/j.phytochem.2003.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two lignans, isochaihulactone and chaihunaphthone, together with eleven known compounds were isolated from the root of Bupleurum scorzonerifolium. Their structures were established on the basis of spectral evidence. In biological testing, eugenin and saikochromone potently inhibited CD28-costimulated activation of human peripheral blood T cells. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：1375 / 1379

页数：5

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