Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells

被引：30

作者：

Miyamoto, Daisei ^{[1
,2
,3
]}

Hasegawa, Sayaka ^{[2
,3
]}

Sriwilaijaroen, Nongluk ^{[4
,5
]}

Yingsakmongkon, Sangchai ^{[4
,6
]}

Hiramatsu, Hiroaki ^{[1
,4
]}

Takahashi, Tadanobu ^{[1
,2
,3
]}

Hidari, Kazuya ^{[1
,2
,3
]}

Guo, Chao-Tan ^{[1
,4
,7
]}

Sakano, Yuichi ^{[2
,8
]}

Suzuki, Takashi ^{[1
,2
,3
]}

Suzuki, Yasuo ^{[1
,3
,4
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, CREST JST, Shizuoka 4228526, Japan

[2] Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Shizuoka 4228526, Japan

[3] Univ Shizuoka, Sch Pharmaceut Sci, Global COE Program Innovat Human Hlth Sci, Shizuoka 4228526, Japan

[4] Chubu Univ, Dept Biomed Sci, Coll Life & Hlth Sci, Aichi 4878501, Japan

[5] Thammasat Univ, Fac Med, Pathum Thani 12120, Thailand

[6] Kasetsart Univ, Dept Microbiol & Immunol, Fac Vet Med, Bangkok 10900, Thailand

[7] Zhejiang Acad Med Sci, Hangzhou 310016, Peoples R China

[8] Japan Hlth Sci Fdn, Chuo Ku, Tokyo 1030001, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2008年 / 31卷 / 02期

关键词：

clarithromycin; influenza virus; anti-influenza drug;

D O I：

10.1248/bpb.31.217

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In vitro effects of macrolide clarithromycin (CAM) on influenza A virus-infected cells were examined using plaque reduction assay by treating cells either before or after viral adsorption. The significant inhibitory effect on influenza virus infection was detected only when the cells were treated with CAM after viral adsorption. The predominant inhibitory effect was observed during 4-7th hour after viral adsorption using viral production assay. CAM did not exhibit inhibitory effects on influenza virus hemagglutination, membrane fusion and viral sialidase activities. These findings indicate that CAM acts on a middle to late stage of the viral replication cycle resulting in inhibition of progeny virus production from the infected cells.

引用

页码：217 / 222

页数：6

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