Bone Morphogenetic Protein signaling in joint homeostasis and disease

被引：95

作者：

Lories, RJU ^{[1
]}

Luyten, FP ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Univ Hosp, Dept Rheumatol, Lab Skeletal Dev & Joint Disorders, B-3000 Louvain, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 03期

关键词：

Bone Morphogenetic Proteins; synovial joint; rheumatoid arthritis; spondyloarthritis; osteoarthritis;

D O I：

10.1016/j.cytogfr.2005.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Despite advances in therapies that target inflammation and tissue destruction in chronic arthritis, stimulation of tissue repair and restoration of joint function, the ultimate goal of treatment, is far from achieved. We introduce a new paradigm that may help to improve our understanding and management of chronic arthritis. The presence or absence of tissue responses distinguishes destructive arthritis, steady-state arthritis and remodeling arthritis. Increasing evidence suggests that reactivation of embryonic molecular pathways is an important mechanism to stimulate postnatal tissue repair. Bone Morphogenetic Proteins (BMPs) have critical roles in skeletal development and joint morphogenesis, but also in postnatal joint homeostasis and joint tissue remodeling. Therefore, modulation of BMP signaling may be an attractive therapeutic target in chronic arthritis to restore homeostasis and function of synovial joints. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：287 / 298

页数：12

共 97 条

[1]

DEVELOPMENT OF CRITERIA FOR THE CLASSIFICATION AND REPORTING OF OSTEOARTHRITIS - CLASSIFICATION OF OSTEOARTHRITIS OF THE KNEE [J].