Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT

被引：39

作者：

Fimia, GM ^{[1
]}

Morlon, A ^{[1
]}

Macho, B ^{[1
]}

De Cesare, D ^{[1
]}

Sassone-Corsi, P ^{[1
]}

机构：

[1] Univ Strasbourg 1, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2001年 / 179卷 / 1-2期

关键词：

transcriptional cascades; spermatogenesis; CREM; ACT;

D O I：

10.1016/S0303-7207(01)00463-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gene CREM plays key physiological and developmental roles within the hypothalamic pituitary-gonadal axis. We have previously shown that CREM is highly expressed in male postmeiotic cells. Spermiogenesis is a complex process by which postmeiotic malt: germ cells differentiate into mature spermatozoa. CREM regulates the expression of a number of post-meiotic genes involved in the process of spermiogenesis. Using homologous recombination we have generated CREM-mutant mice that display a complete block at the first step of spermiogenesis, The molecular mechanism by which CREM elicits its regulatory function involves ACT (Activator of CREM in Testis), a testis-specific coactivator constituted by a repeat of four and half LIM domains. ACT is coordinately expressed with CREM. associates with it and confers a powerful transcriptional activation function. It is able to bypass the classical requirement of CREM phosphorylation and recruiting of CBP. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 23

页数：7

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