The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)

被引：57

作者：

McKie, AT

Barlow, DJ

机构：

[1] Kings Coll London, Div Life Sci, London SE1 9NN, England

[2] Kings Coll London, Dept Pharm, London SE1 9NN, England

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 447卷 / 05期

关键词：

iron; transport; basolateral; duodenum; haemochromatosis; Ireg1; ferroportin; MTP1; macrophage;

D O I：

10.1007/s00424-003-1102-3

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The iron regulated-transporter-1 (Ireg1, also known as ferroportin or metal transporter protein-1, MTP1) appears to be the sole member of the SLC40 transporter family. It functions as a universal efflux pathway for iron in a number of cell types. The protein is most highly expressed in mature enterocytes of the duodenum, in syncytiotrophoblasts, which separate foetal and maternal circulations in the placenta, and in macrophages responsible for recycling iron from breakdown of aged red blood cells.

引用

页码：801 / 806

页数：6

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