Kidney transplantation: Mechanisms of rejection and acceptance

被引：158

作者：

Cornell, Lynn D. ^{[1
]}

Smith, R. Neal

Colvin, Robert B.

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2008年 / 3卷

关键词：

renal allograft; acute rejection; chronic rejection; antibody; accommodation;

D O I：

10.1146/annurev.pathmechdis.3.121806.151508

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We describe the Molecular and cellular mechanisms believed to be responsible for the rejection of renal allografts, including acute T cell-mediated rejection, acute antibody-mediated (humoral) rejection, rejection mediated by the innate immune system, and chronic rejection. We present mechanisms of graft acceptance, including accommodation, regulation, and tolerance. Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models.

引用

页码：189 / 220

页数：32

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