Genetic Features of blaNDM-1-Positive Enterobacteriaceae

被引：359

作者：

Poirel, Laurent ^{[1
]}

Dortet, Laurent ^{[1
]}

Bernabeu, Sandrine ^{[1
]}

Nordmann, Patrice ^{[1
]}

机构：

[1] Hop Bicetre, Assistance Publ Hop Paris, Serv Bacteriol Virol, Fac Med Paris Sud,INSERM Emerging Resistance Anti, F-94275 Le Kremlin Bicetre, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 11期

关键词：

RESISTANT ESCHERICHIA-COLI; NDM-1; CARBAPENEMASE; MULTIPLEX PCR; EMERGENCE; DISSEMINATION; DNA;

D O I：

10.1128/AAC.00585-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetic features associated with the bla(NDM-1) gene were investigated in 6 Escherichia coli, 7 Klebsiella pneumoniae, 1 Citrobacter freundii, 1 Proteus mirabilis, and 1 Providencia stuartii isolate of worldwide origin. Clonal diversity was observed for both E. coli and K. pneumoniae. The bla(NDM-1) gene was carried by different plasmid types (IncA/C, IncF, IncL/M, or untypeable) and was likely chromosome borne in two isolates. The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including beta-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes.

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页码：5403 / 5407

页数：5

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