BleeMACS: rationale and design of the study

被引：33

作者：

D'Ascenzo, Fabrizio ^{[1
]}

Abu-Assi, Emad ^{[2
]}

Raposeiras-Roubin, Sergio ^{[2
]}

Simao Henriques, Jose Paulo ^{[3
]}

Saucedo, Jorge ^{[4
]}

Ramon Gonzalez-Juanatey, Jose ^{[2
]}

Wilton, Stephen B. ^{[5
]}

Kikkert, Wouter J. ^{[3
]}

Nunez-Gil, Ivan ^{[6
]}

Ariza-Sole, Albert ^{[7
]}

Song, Xiantao ^{[8
]}

Alexopoulos, Dimitrios ^{[9
]}

Liebetrau, Christoph ^{[10
]}

Kawaji, Tetsuma ^{[11
]}

Moretti, Claudio ^{[1
]}

Huczek, Zenon ^{[12
]}

Nie, Shao-Ping ^{[13
]}

Fujii, Toshiharu ^{[14
]}

Correia, Luis Claudio ^{[15
]}

Kawashiri, Masa-aki ^{[16
]}

Maria Garcia-Acuna, Jose ^{[2
]}

Southern, Danielle ^{[5
]}

Alfonso, Emilio ^{[6
]}

Terol, Belen

Garay, Alberto ^{[7
]}

Zhang, Dongfeng ^{[8
]}

Chen, Yalei ^{[8
]}

Xanthopoulou, Ioanna ^{[9
]}

Osman, Neriman ^{[10
]}

Moellmann, Helge ^{[10
]}

Shiomi, Hiroki ^{[11
]}

Giordana, Francesca ^{[1
]}

Scarano, Silvia ^{[1
]}

Gaita, Fiorenzo ^{[1
]}

Kowara, Michal ^{[12
]}

Filipiak, Krzysztof J. ^{[12
]}

Wang, Xiao ^{[13
]}

Yan, Yan ^{[13
]}

Fan, Jing-Yao ^{[13
]}

Ikari, Yuji ^{[14
]}

Nakahayshi, Takuya ^{[16
]}

Sakata, Kenji ^{[16
]}

Yamagishi, Masakazu ^{[16
]}

Kalpak, Oliver ^{[17
]}

Kedev, Sasko ^{[17
]}

机构：

[1] Citta Salute & Sci, Dipartimento Sci Med, Div Cardiol, Turin, Italy

[2] Univ Clin Hosp, Santiago De Compostela, Spain

[3] Univ Acad Med Ctr, Amsterdam, Netherlands

[4] NorthShore Univ Hosp, Chicago, IL USA

[5] Libin Cardiovasc Inst Alberta, Calgary, AB, Canada

[6] San Carlos Hosp, Madrid, Spain

[7] Bellvitge Hosp, Barcelona, Spain

[8] Anzhen Hosp, Beijing, Peoples R China

[9] Univ Patras Hosp, Athens, Greece

[10] Kerckhoff Heart & Thorax Ctr, Frankfurt, Germany

[11] Univ Clin Hosp, Kyoto, Japan

[12] Univ Clin Hosp, Warsaw, Poland

[13] Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China

[14] Tokai Univ, Sch Med, Tokyo, Japan

[15] Univ Bahian, Sch Med, Salvador, BA, Brazil

[16] Kanazawa Univ, Grad Sch Med, Div Cardiovasc Med, Kanazawa, Ishikawa, Japan

[17] Univ Clin Cardiol, Skopje, North Macedonia

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2016年 / 17卷 / 10期

基金：

日本学术振兴会;

关键词：

acute coronary syndrome; bleedings; BleeMACS; score; ELEVATION MYOCARDIAL-INFARCTION; TISSUE-PLASMINOGEN-ACTIVATOR; ACUTE CORONARY SYNDROMES; RISK; METAANALYSIS; CLOPIDOGREL; STREPTOKINASE; COMPLICATIONS; THROMBOLYSIS; OUTCOMES;

D O I：

10.2459/JCM.0000000000000362

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

BackgroundBleeding events after an acute coronary syndrome have a negative impact on prognosis. Available risk scores are limited by suboptimal accuracy, prediction of only in-hospital events and absence of patients treated with new antiplatelet agents in the current era of widespread use of percutaneous coronary intervention.DesignThe BleeMACS (Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome) project is a multicenter investigator-initiated international retrospective registry that enrolled more than 15000 patients discharged with a definitive diagnosis of acute coronary syndrome and treated with percutaneous revascularization. The primary end point is the incidence of major bleeding events requiring hospitalization and/or red cell transfusion concentrates within 1 year. An integer risk score for bleeding within the first year after hospital discharge will be developed from a multivariate competing-risks regression.ConclusionThe BleeMACS registry collaborative will allow development and validation of a risk score for prediction of major bleeding during follow-up for patients receiving contemporary therapies for acute coronary syndrome.

引用

页码：744 / 749

页数：6

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