The role of leptin in the regulation of energy balance and adiposity

被引:50
作者
van Dijk, G [1 ]
机构
[1] Univ Groningen, Sch Behav & Cognit Neurosci, Div Neuroendocrinol, Dept Anim Physiol, NL-9750 AA Haren, Netherlands
关键词
food intake; body weight; hypothalamus; neuropeptide; metabolism;
D O I
10.1046/j.1365-2826.2001.00707.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since its discovery, leptin (a 167-amino acid product of the OB gene) has quickly moved to the forefront as an important hormone for regulation of energy balance. It closes a feedback loop from adipose tissue to hypothalamic neuropeptide-containing neural circuitry involved in regulation of food intake and neuroendocrine/autonomic outflow. While increased central leptin signalling reduces adiposity via a reduction in food intake, it also has remarkable metabolic effects that promote leanness, independent of food intake. These include: (i) increased energy expenditure, (ii) in-place degradation of fat, and (iii) increased thermogenesis. Hypothalamic neurones that synthesize corticotropin releasing hormone and melanocortins (i.e. alpha -melanocyte-stimulating hormone and agouti-related protein) are likely effector pathways that mediate the anorexigenic and metabolic effects of leptin. Activation of sympathetic outflow (via neuropeptidergic effector pathways of central leptin) to a number of tissues that store fat might be an important mechanism through which these peripheral metabolic effects are elicited. It is proposed that these peripheral metabolic effects contribute to the satiating properties of leptin.
引用
收藏
页码:913 / 921
页数:9
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