A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

被引：525

作者：

Hashimoto, Y

Niikura, T

Tajima, H

Yasukawa, T

Sudo, H

Ito, Y

Kita, Y

Kawasumi, M

Kouyama, K

Doyu, M

Sobue, G

Koide, T

Tsuji, S

Lang, JC

Kurokawa, K

Nishimoto, I ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Pharmacol, Tokyo 1608582, Japan

[2] Keio Univ, Sch Med, Dept Neurosci, Tokyo 1608582, Japan

[3] Nagoya Univ, Sch Med, Dept Neurol, Nagoya, Aichi 4660065, Japan

[4] Niigata Univ, Sch Med, Brain Res Inst, Dept Neurol, Niigata 9518122, Japan

[5] Ecole Polytech, Inst Europeen Chim & Biol, F-33402 Talence, France

[6] Tokai Univ, Sch Med, Dept Med, Isehara, Kanagawa 2591100, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 11期

关键词：

D O I：

10.1073/pnas.101133498

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by A beta amyloid, without effect on death by Q79 or superoxide dismutase-l mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN, This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.

引用

页码：6336 / 6341

页数：6

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