Mortality risk in children with epilepsy: The Dutch Study of Epilepsy in Childhood

被引:81
作者
Callenbach, PMC
Westendorp, RGJ
Geerts, AT
Arts, WFM
Peeters, EAJ
van Donselaar, VA
Peters, ACB
Stroink, H
Brouwer, OF
机构
[1] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
[3] Univ Rotterdam Hosp, Dept Neurol, Rotterdam, Netherlands
[4] Univ Rotterdam Hosp, Dept Pediat Neurol, Rotterdam, Netherlands
[5] Sophia Childrens Univ Hosp, Rotterdam, Netherlands
[6] Westeinde Ziekenhuis, Dept Neurol, The Hague, Netherlands
[7] Juliana Childrens Hosp, Dept Neurol, The Hague, Netherlands
[8] Univ Utrecht Hosp, Dept Pediat Neurol, Utrecht, Netherlands
[9] Wilhelmina Childrens Hosp, Utrecht, Netherlands
[10] St Elizabeth Hosp, Dept Pediat Neurol, Tilburg, Netherlands
关键词
mortality; epilepsy; children; follow-up; Netherlands;
D O I
10.1542/peds.107.6.1259
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective. Long-term follow-up studies of patients with epilepsy have revealed an increased mortality risk compared with the general population. Mortality of children who have epilepsy in modern times is as yet unknown. Therefore, the objective of this study was to determine mortality of children who have epilepsy in comparison with the general population. Methods. Between August 1988 and August 1992, 472 children, aged 1 month to 16 years, who presented in 1 of the participating hospitals with 2 or more newly diagnosed unprovoked seizures or at least 1 status epilepticus were enrolled in the study. All children were followed for 5 years or until death. The number of deaths observed during follow-up was compared with the expected number of deaths in the same age group in the general population in the Netherlands. Results. Nine children died during follow-up, amounting to a mortality rate of 3.8/1000 person-years, which is sevenfold higher than expected (95% confidence interval = 2.4-11.5). No deaths were observed among the 328 children who had epilepsy of nonsymptomatic cause. All deceased children had epilepsy that was caused by a static or progressive neurologic disorder (mortality risk = 22.9; 95% confidence interval = 7.9-37.9). None of them died from sudden unexpected and unexplained death of epilepsy. Conclusions. In our cohort, we found no indication that children who have nonsymptomatic epilepsy have an increased mortality risk compared with the general population, whereas children who have symptomatic epilepsy have a 20-fold increased mortality risk. These data provide guidance for counseling parents of children who have epilepsy.
引用
收藏
页码:1259 / 1263
页数:5
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