Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics

被引：7

作者：

Angrave, FE ^{[1
]}

Avery, SV ^{[1
]}

机构：

[1] Univ Nottingham, Sch Life & Environm Sci, Nottingham NG7 2RD, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 10期

关键词：

D O I：

10.1128/AAC.45.10.2939-2942.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cu,Zn superoxide dismutase (Sod1) is required for insusceptibility of Saccharomyces cerevisiae to oxytetracycline (OTC). Here we report that Sod1 is also required for insusceptibility to doxycycline (DOX). Furthermore, among a range of antioxidant and redox balance mutants, mac1 and ctr1 deletion strains exhibited marked sensitization to OTC and DOX. Certain mutants exhibited a slight sensitivity to methacycline and minocycline. Addition of copper suppressed antibiotic sensitivity. Thus, intracellular copper as well as superoxide dismutase can be critical for eukaryotic tolerance of several tetracycline antibiotics.

引用

页码：2939 / 2942

页数：4

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