Hepatitis E

被引：849

作者：

Kamar, Nassim ^{[1
,2
,3
]}

Bendall, Richard

Legrand-Abravanel, Florence ^{[2
,3
,5
]}

Xia, Ning-Shao ^{[6
]}

Ijaz, Samreen ^{[7
]}

Izopet, Jacques ^{[2
,3
,5
]}

Dalton, Harry R. ^{[4
,8
,9
]}

机构：

[1] CHU Rangueil, Dept Nephrol Dialysis & Organ Transplantat, F-31054 Toulouse, France

[2] Ctr Physiopathol Toulouse Purpan, Toulouse, France

[3] Univ Toulouse 3, F-31062 Toulouse, France

[4] Royal Cornwall Hosp Trust, Cornwall Gastrointestinal Unit, Truro, England

[5] CHU Purpan, Dept Virol, Toulouse, France

[6] Xiamen Univ, Sch Publ Hlth, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen, Peoples R China

[7] Hlth Protect Agcy, Microbiol Serv Colindale, Virus Reference Dept, London, England

[8] Univ Exeter, Peninsula Coll Med & Dent, European Ctr Environm & Human Hlth, Truro, England

[9] Univ Plymouth, Peninsula Coll Med & Dent, European Ctr Environm & Human Hlth, Truro, England

来源：

LANCET | 2012年 / 379卷 / 9835期

关键词：

E VIRUS-INFECTION; CHRONIC LIVER-DISEASE; ORGAN-TRANSPLANT RECIPIENTS; HUMAN-IMMUNODEFICIENCY-VIRUS; PEGYLATED INTERFERON-ALPHA; CELL-CULTURE-SYSTEM; BLOOD-DONORS; RISK-FACTORS; E VACCINE; NEUROLOGIC DISORDERS;

D O I：

10.1016/S0140-6736(11)61849-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatitis E virus (HEV) was discovered during the Soviet occupation of Afghanistan in the 1980s, after an outbreak of unexplained hepatitis at a military camp. A pooled faecal extract from affected soldiers was ingested by a member of the research team. He became sick, and the new virus (named HEV), was detected in his stool by electron microscopy. Subsequently, endemic HEV has been identified in many resource-poor countries. Globally, HEV is the most common cause of acute viral hepatitis. The virus was not initially thought to occur in developed countries, but recent reports have shown this notion to be mistaken. The aim of this Seminar is to describe recent discoveries regarding HEV, and how they have changed our understanding of its effect on human health worldwide.

引用

页码：2477 / 2488

页数：12

共 143 条

[1] Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death [J].