Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour

被引：9

作者：

Heinonen, K

Rao, PN

Slack, JL

Cruz, J

Bloomfield, CD

Mrozek, K

机构：

[1] ROSWELL PK CANC INST,DIV MED,CYTOGENET RES LAB,BUFFALO,NY 14263

[2] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PEDIAT,WINSTON SALEM,NC 27103

[3] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MED,WINSTON SALEM,NC 27103

[4] CANC & LEUKEMIA GRP B,CHICAGO,IL

[5] KUOPIO UNIV HOSP,DEPT CLIN CHEM,SF-70210 KUOPIO,FINLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 93卷 / 03期

关键词：

AML; germ cell tumour; isochromosome; 12p; karyotyping;

D O I：

10.1046/j.1365-2141.1996.d01-1687.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An isochromosome 12p [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT. We report two i(12p)-positive AML cases without clinical evidence of GCT. One patient with AML-M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML-M3 with t(15;17)(q22;q11-12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15:17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.

引用

收藏

页码：677 / 680

页数：4

相关论文

共 15 条

[1] CLINICAL RELEVANCE OF THE I(12P) MARKER CHROMOSOME IN GERM-CELL TUMORS [J].

BOSL, GJ ;

ILSON, DH ;

RODRIGUEZ, E ;

MOTZER, RJ ;

REUTER, VE ;

CHAGANTI, RSK .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (05) :349-355

[2] ASSOCIATED LEUKEMIA AND MIXED GEM CELL TUMOR IN A PATIENT WITH GONADAL-DYSGENESIS [J].

KAPLAN, SS ;

BORNSTEIN, SG ;

CHRISTOPHERSON, WA ;

SURTI, U .

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 1991, 35 (01) :83-88

[3] CYTOGENETIC AND IMMUNOHISTOCHEMICAL EVIDENCE FOR THE GERM-CELL ORIGIN OF A SUBSET OF ACUTE LEUKEMIAS ASSOCIATED WITH MEDIASTINAL GERM-CELL TUMORS [J].

LADANYI, M ;

SAMANIEGO, F ;

REUTER, VE ;

MOTZER, RJ ;

JHANWAR, SC ;

BOSL, GJ ;

CHAGANTI, RSK .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (03) :221-227

[4] CYTOGENETIC STUDY OF 130 CHILDHOOD ACUTE NONLYMPHOCYTIC LEUKEMIAS [J].

LEVERGER, G ;

BERNHEIM, A ;

DANIEL, MT ;

FLANDRIN, G ;

SCHAISON, G ;

BERGER, R .

MEDICAL AND PEDIATRIC ONCOLOGY, 1988, 16 (04) :227-232

[5] OVARIAN GERM-CELL TUMOR EVOLVING TO MYELODYSPLASIA [J].

MASCARELLO, JT ;

CAJULIS, TR ;

BILLMAN, GF ;

SPRUCE, WE .

GENES CHROMOSOMES & CANCER, 1993, 7 (04) :227-230

[6] REVERSE TRANSCRIPTION POLYMERASE CHAIN-REACTION FOR THE REARRANGED RETINOIC ACID RECEPTOR-ALPHA CLARIFIES DIAGNOSIS AND DETECTS MINIMAL RESIDUAL DISEASE IN ACUTE PROMYELOCYTIC LEUKEMIA [J].

MILLER, WH ;

KAKIZUKA, A ;

FRANKEL, SR ;

WARRELL, RP ;

DEBLASIO, A ;

LEVINE, K ;

EVANS, RM ;

DMITROVSKY, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2694-2698

[7]

MITELMAN F, 1994, CATALOG CHROMOSOME A

[8] MALIGNANT HEMATOLOGIC DISORDERS ARISING FROM MEDIASTINAL GERM-CELL TUMORS - A REVIEW OF CLINICAL AND BIOLOGIC FEATURES [J].

NICHOLS, CR .

LEUKEMIA & LYMPHOMA, 1991, 4 (04) :221-229

[9] MEDIASTINAL GERM-CELL TUMOR WITH SECONDARY NONGERM CELL MALIGNANCY, AND EXTENSIVE HEMATOPOIETIC ACTIVITY - PATHOLOGY, DNA-PLOIDY, AND KARYOTYPING [J].

OOSTERHUIS, JW ;

VANDENBERG, E ;

DEJONG, B ;

TIMENS, W ;

CASTEDO, SMMJ ;

RAMMELOO, RHU ;

SLEIJFER, DT .

CANCER GENETICS AND CYTOGENETICS, 1991, 54 (02) :183-195

[10]

ORAZI A, 1993, CANCER, V71, P3873, DOI 10.1002/1097-0142(19930615)71:12<3873::AID-CNCR2820711214>3.0.CO