Synthesis and in vitro antibacterial evaluation of N-[5-(5-vitro-2-thienyl)-1, 3,4-thiadiazole-2-yl] piperazinyl quinolones

A series of N-[5-(5-vitro-2-thienyl)-1,3,4-thiadiazole-2-yl]piperazinyl quinolones (7a-c) were synthesized and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that compounds 7a-c had strong and better activity against tested Gram-positive organisms than the reference quinolones such as ciprofloxacin, norfloxacin and enoxacin. However, all three compounds were nearly inactive against Gram-negative bacteria. Compound 7a (ciprofloxacin analogue) was the most active compound against Gram-positive bacteria (MIC=0.008-0.015 mug mL(-1)). (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.