Gene-culture coevolution between cattle milk protein genes and human lactase genes

被引：184

作者：

Beja-Pereira, A

Luikart, G

England, PR

Bradley, DG

Jann, OC

Bertorelle, G

Chamberlain, AT

Nunes, TP

Metodiev, S

Ferrand, N

Erhardt, G

机构：

[1] Univ Grenoble 1, CNRS, UMR 5553, Lab Ecol Alpine Genom Populat & Biodivers, F-38041 Grenoble 9, France

[2] Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, P-4485661 Vairao, Portugal

[3] Univ Porto, Fac Ciencias, Seccao Autonoma Ciencias Agrarias, P-4485661 Vairao, Portugal

[4] Univ Dublin Trinity Coll, Dept Genet, Smurfit Inst, Dublin 2, Ireland

[5] Univ Giessen, Inst Tierzucht & Haustiergenet, D-35390 Giessen, Germany

[6] Univ Ferrara, Dept Biol, I-44100 Ferrara, Italy

[7] Univ Sheffield, Dept Archaeol & Prehist, Sheffield S1 4ET, S Yorkshire, England

[8] Polo Univ Ajuda, Fac Med Vet, DETSA, UISEE,CIISA, P-1300477 Lisbon, Portugal

[9] Thracian Univ, Fac Agr, Dept Anim Breeding & Genet, Stara Zagora 6000, Bulgaria

[10] Fac Ciencias Praca Gomes Teixeira, Dept Zool Antropol, P-4099002 Oporto, Portugal

来源：

NATURE GENETICS | 2003年 / 35卷 / 04期

关键词：

D O I：

10.1038/ng1263

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Milk from domestic cows has been a valuable food source for over 8,000 years, especially in lactose-tolerant human societies that exploit dairy breeds. We studied geographic patterns of variation in genes encoding the six most important milk proteins in 70 native European cattle breeds. We found substantial geographic coincidence between high diversity in cattle milk genes, locations of the European Neolithic cattle farming sites (>5,000 years ago) and present-day lactose tolerance in Europeans. This suggests a gene-culture coevolution between cattle and humans.

引用

页码：311 / 313

页数：3

共 15 条

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