Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "Click" chemistry

被引：705

作者：

Killops, Kato L. ^{[1
,2
]}

Campos, Luis M. ^{[1
,2
]}

Hawker, Craig J. ^{[1
,2
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Dept Mat, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 15期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/ja8006325

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dendrimers up to the fourth generation were successfully prepared via the divergent growth strategy using a combination of thiol-ene "click" chemistry and traditional esterification reactions. The thiol-ene reactions were conducted under solvent-free, ambient conditions at room temperature by irradiating with UV light. The fourth-generation dendrimers were subsequently functionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions.

引用

页码：5062 / +

页数：4

共 31 条

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