Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats

被引：160

作者：

González, R ^{[1
]}

Rodríguez, S ^{[1
]}

Romay, C ^{[1
]}

Ancheta, O ^{[1
]}

González, A ^{[1
]}

Armesto, J ^{[1
]}

Remirez, D ^{[1
]}

Merino, N ^{[1
]}

机构：

[1] Natl Ctr Sci Res, Dept Pharmacol, Havana 6880, Cuba

来源：

PHARMACOLOGICAL RESEARCH | 1999年 / 39卷 / 01期

关键词：

phycocyanin; anti-inflammatory; acetic acid; colitis; rat;

D O I：

10.1006/phrs.1998.0409

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anti-inffammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats. Phycocyanin (150, 200 and 300 mg kg(-1) p.o.) was administered 30 min before induction of colitis with enema of 1 mi of 4% acetic acid per rat. Twenty-four hours later myeloperoxidase (MPO) activity was determined as well as histopathological and ultrastructural studies were carried out in colonic tissue. Phycocyanin substantially reduced MPO activity which was increased in the control colitis group. Also, histopathological and ultrastructural studies showed inhibition in inflammatory cell infiltration and reduction to some extent in colonic damage in rats treated with phycocyanin. The probable role of antioxidative and the scavenging properties of phycocyanin against reactive oxygen species in the anti-colitic effect is discussed in this paper. To our knowledge this is the first report an the anti-inflammatory effect of phycocyanin in an experimental model of colitis. (C) 1999 The Italian Pharmacological Society.

引用

页码：55 / 59

页数：5

共 18 条

[1] THE ANTIINFLAMMATORY MOIETY OF SULFASALAZINE, 5-AMINOSALICYLIC ACID, IS A RADICAL SCAVENGER [J].