Interleukin-8 promoter polymorphism-251A/T is a risk factor for age-related macular degeneration

被引：60

作者：

Goverdhan, S. V. ^{[1
,2
]}

Ennis, S. ^{[3
]}

Hannan, S. R. ^{[2
]}

Madhusudhana, K. C. ^{[2
]}

Cree, A. J. ^{[1
]}

Luff, A. J. ^{[2
]}

Lotery, A. J. ^{[1
,2
]}

机构：

[1] Southampton Gen Hosp, Clin Neurosci Div, Southampton SO16 6YD, Hants, England

[2] Southampton Gen Hosp, Southampton Eye Unit, Southampton SO16 6YD, Hants, England

[3] Southampton Gen Hosp, Div Human Genet, Southampton SO16 6YD, Hants, England

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 2008年 / 92卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/bjo.2007.123190

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD). Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1 beta -511C/ T, IL6 -174C/ G, IL8 -251A/ T and anti-inflammatory IL10 -1082G/ A cytokine polymorphisms using the 59 nuclease TaqMan (R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies. Results: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls ( p= 0.037, OR= 1.21, 95% CI= 1.01 to 1.44). Adjusting for age, sex, body mass index ( BMI), current smoking and past smoking status did not alter the AMD association significantly ( corrected p value= 0.043, OR= 1.23, 95% CI= 1.0 to 1.50). Conclusion: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.

引用

页码：537 / 540

页数：4

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