Bayesian inference for stochastic multitype epidemics in structured populations via random graphs

被引:38
作者
Demiris, N
O'Neill, PD
机构
[1] Univ Nottingham, Sch Math Sci, Nottingham NG7 2RD, England
[2] MRC, Biostat Unit, Cambridge CB2 2BW, England
关键词
Bayesian inference; epidemics; Markov chain Monte Carlo methods; Metropolis-Hastings algorithm; random graphs; stochastic epidemic models;
D O I
10.1111/j.1467-9868.2005.00524.x
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
The paper is concerned with new methodology for statistical inference for final outcome infectious disease data using certain structured population stochastic epidemic models. A major obstacle to inference for such models is that the likelihood is both analytically and numerically intractable. The approach that is taken here is to impute missing information in the form of a random graph that describes the potential infectious contacts between individuals. This level of imputation overcomes various constraints of existing methodologies and yields more detailed information about the spread of disease. The methods are illustrated with both real and test data.
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页码:731 / 745
页数:15
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