Electrophysiological estimate of human cortical magnification

被引:52
作者
Slotnick, SD [1 ]
Klein, SA
Carney, T
Sutter, EE
机构
[1] Johns Hopkins Univ, Dept Psychol, Baltimore, MD 21218 USA
[2] Univ Calif Berkeley, Dept Vis Sci, Berkeley, CA 94720 USA
[3] Neurometr Inst, Berkeley, CA 94720 USA
[4] Smith Kettlewell Eye Res Inst, San Francisco, CA 94115 USA
关键词
cortical magnification; primary visual cortex; human; monkey; visual evoked potential; dipole source localization; functional magnetic resonance imaging; cortical stimulation; psychophysics;
D O I
10.1016/S1388-2457(01)00561-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The cortical magnification factor characterizes the area of human primary visual cortex activated by a stimulus as a function of angular distance from an observer's line of sight. This study estimates human cortical magnification using an electrophysiological method with excellent temporal resolution: visual evoked potential (VEP) dipole source localization. Methods: For each of 60 independently modulated checkerboard patches within the central 18 deg of the visual field, location, orientation, magnitude, and time-course of the dipole current source that best described the VEP distribution across a multi-electrode array was obtained. At numerous eccentricities, cortical magnification was determined using two different techniques: (1) the distance between each pair of adjacent stimulus patches was matched to the corresponding distance between adjacent cortical sources; and (2) the area of each stimulus patch was matched to the magnitude of the corresponding cortical source (which was assumed to be proportional to cortical area). Results: The estimates of human cortical magnification using our electrophysiological method were similar to previous estimates from psychophysics, cortical stimulation, and functional magnetic resonance imaging. Conclusions: The concordance of results provided by these disparate technologies, with differing spatial and temporal limitations, supports their combination in studying the spatio-temporal dynamics of human brain function. (C) 2001 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:1349 / 1356
页数:8
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