Effectors for the Rho GTPases

被引：282

作者：

Aspenström, P ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Ctr Biomed, S-75224 Uppsala, Sweden

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(99)80011-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Rho GTPases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulators and target proteins of these GTPases. Recent implications of Rho effecters in human disease, however, might give important clues to how specificity is achieved in cell signalling pathways employing Rho GTPases.

引用

页码：95 / 102

页数：8

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